Mambalgin-1 vs Conantokin-G
Head-to-head comparison of Mambalgin-1 (Mambalgin-1 from Dendroaspis polylepis venom) and Conantokin-G (Conantokin-G from Conus geographus venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Mambalgin-1 | Conantokin-G |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Mambalgin-1 from Dendroaspis polylepis venom | Conantokin-G from Conus geographus venom |
| Molecular Weight | 6,300 Da | 2,150 Da |
| Half-Life | Minutes to hours | Minutes to hours |
| Amino Acids | 57 | 17 |
| Typical Dose | 0.1-1 nmol intrathecal|10-100 nM in vitro|single-dose rodent studies | 0.1-10 nmol intrathecal|10-1000 nM in vitro|single-dose rodent studies |
| Route | Intrathecal | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 55 | 95 |
| Research Status | Pre-clinical | Pre-clinical |
Mambalgin-1 Benefits
- ✓ASIC channel inhibition
- ✓non-opioid analgesia research
- ✓sensory-neuron physiology
- ✓lead optimization for pain therapeutics
Conantokin-G Benefits
- ✓NMDA receptor antagonism
- ✓seizure-model research
- ✓excitatory neurotransmission mapping
- ✓pain-mechanism studies
Mambalgin-1 Dosing
Intrathecal pain-behavior studies|ASIC1a/ASIC1b electrophysiology|Acute dosing in rodents
Conantokin-G Dosing
Intrathecal administration in seizure/pain models|NMDA receptor assays|In vitro excitation studies
Mambalgin-1 Side Effects
- ⚠Hypoactivity at high dose
- ⚠off-target ASIC blockade
- ⚠local irritation
Conantokin-G Side Effects
- ⚠Sedation or dizziness in animals
- ⚠motor effects at high exposure
- ⚠off-target NMDA modulation
Research Overview
Mambalgin-1
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
Conantokin-G
Research has shown conantokin-G can suppress NMDA-mediated responses in a sequence- and modification-dependent manner. It remains a classic marine peptide tool for probing glutamatergic signaling and analgesia-related pathways.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.