Mambalgin-1 vs Plitidepsin
Head-to-head comparison of Mambalgin-1 (Mambalgin-1 from Dendroaspis polylepis venom) and Plitidepsin (Dehydrodidemnin B (Plitidepsin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Mambalgin-1 | Plitidepsin |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Mambalgin-1 from Dendroaspis polylepis venom | Dehydrodidemnin B (Plitidepsin) |
| Molecular Weight | 6,300 Da | 1110.3 Da |
| Half-Life | Minutes to hours | Approximately 44 hours |
| Amino Acids | 57 | N/A |
| Typical Dose | 0.1-1 nmol intrathecal|10-100 nM in vitro|single-dose rodent studies | 1.5 mg/m2 IV |
| Route | Intrathecal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 55 | 240 |
| Research Status | Pre-clinical | Clinical |
Mambalgin-1 Benefits
- ✓ASIC channel inhibition
- ✓non-opioid analgesia research
- ✓sensory-neuron physiology
- ✓lead optimization for pain therapeutics
Plitidepsin Benefits
- ✓antineoplastic
- ✓antiviral
- ✓pro-apoptotic
- ✓anti-inflammatory
Mambalgin-1 Dosing
Intrathecal pain-behavior studies|ASIC1a/ASIC1b electrophysiology|Acute dosing in rodents
Plitidepsin Dosing
1.5 mg/m2 IV infusion in oncology trials|q21d or similar intermittent schedules|dose escalation and combination protocols in studies
Mambalgin-1 Side Effects
- ⚠Hypoactivity at high dose
- ⚠off-target ASIC blockade
- ⚠local irritation
Plitidepsin Side Effects
- ⚠nausea
- ⚠fatigue
- ⚠transaminase elevation
Research Overview
Mambalgin-1
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
Plitidepsin
Plitidepsin has been studied for its ability to disrupt eEF1A-dependent pathways, induce oxidative stress, and suppress tumor cell growth. It has reached clinical oncology development and was also evaluated as a candidate against SARS-CoV-2 in the literature.
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