Macimorelin vs Modified GRF(1-29)
Head-to-head comparison of Macimorelin (Macimorelin acetate (AEZS-130)) and Modified GRF(1-29) ([D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Macimorelin | Modified GRF(1-29) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Macimorelin acetate (AEZS-130) | [D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | about 4-6 hours | 10-30 minutes |
| Amino Acids | N/A | 29 |
| Typical Dose | 0.5 mg/kg single oral dose | 50-300 mcg |
| Route | Oral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 150 |
| Research Status | Clinical | Investigational |
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Modified GRF(1-29) Benefits
- ✓enhanced GH release
- ✓greater peptide stability
- ✓IGF-1 support research
- ✓longer receptor engagement
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Modified GRF(1-29) Dosing
50-100 mcg SC for acute GH-response studies|100-300 mcg SC in monitored research protocols|repeat dosing in short investigative cycles with GH/IGF-1 tracking
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Modified GRF(1-29) Side Effects
- ⚠headache
- ⚠water retention
- ⚠injection-site irritation
Research Overview
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
Modified GRF(1-29)
Modified GRF(1-29) has been studied as a practical GHRH analog for boosting GH release while improving peptide stability versus the native fragment. It is a standard reference compound in experimental work on growth hormone pulsatility and analog design.
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