Macimorelin vs Capromorelin
Head-to-head comparison of Macimorelin (Macimorelin acetate (AEZS-130)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Macimorelin | Capromorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Macimorelin acetate (AEZS-130) | Capromorelin hydrochloride |
| Molecular Weight | N/A | N/A |
| Half-Life | about 4-6 hours | about 2-3 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 0.5 mg/kg single oral dose | 0.25-2 mg/kg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 55 |
| Research Status | Clinical | Clinical |
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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