Insulin Aspart vs Exendin-4
Head-to-head comparison of Insulin Aspart (Insulin aspart (B28-Asp human insulin analog)) and Exendin-4 (Exendin-4 (synthetic exenatide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Insulin Aspart | Exendin-4 |
|---|---|---|
| Category | Diabetes & Metabolic | Diabetes & Metabolic |
| Full Name | Insulin aspart (B28-Asp human insulin analog) | Exendin-4 (synthetic exenatide) |
| Molecular Weight | 5825.8 Da | 4186 Da |
| Half-Life | About 1-3 hours | 2.4 hours |
| Amino Acids | 51 | 39 |
| Typical Dose | 0.05-0.2 U/kg per meal | 5-10 mcg twice daily |
| Route | Subcutaneous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 11000 | 1800 |
| Research Status | Approved | Clinical |
Insulin Aspart Benefits
- ✓Fast post-meal glucose lowering
- ✓Predictable onset
- ✓Flexible mealtime administration
- ✓Compatible with pump therapy
Exendin-4 Benefits
- ✓beta-cell survival
- ✓glucose-stimulated insulin secretion
- ✓reduced glucolipotoxicity
- ✓lowered HbA1c in clinical use
Insulin Aspart Dosing
Inject SC immediately before meals|Titrate using glucose monitoring and carbohydrate intake|Can be used in insulin pumps or basal-bolus regimens
Exendin-4 Dosing
5 mcg SC twice daily for 4 weeks|increase to 10 mcg SC twice daily if tolerated|research: 0.1-1 µM in vitro or 1-10 µg/kg in animals
Insulin Aspart Side Effects
- ⚠Hypoglycemia
- ⚠Injection-site reactions
- ⚠Weight gain
Exendin-4 Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠injection-site reactions
Research Overview
Insulin Aspart
Research consistently shows faster onset and earlier peak action than regular human insulin. It is commonly studied for meal-time glycemic control and pump-based insulin delivery.
Exendin-4
Exendin-4 helped establish GLP-1 receptor biology in diabetes and remains a classic beta-cell protective peptide. Preclinical studies show reduced beta-cell apoptosis, improved insulin content, and better islet function under metabolic stress.
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