Insulin Aspart vs GLP-1
Head-to-head comparison of Insulin Aspart (Insulin aspart (B28-Asp human insulin analog)) and GLP-1 (Glucagon-like peptide-1 (7-36 amide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Insulin Aspart | GLP-1 |
|---|---|---|
| Category | Diabetes & Metabolic | Diabetes & Metabolic |
| Full Name | Insulin aspart (B28-Asp human insulin analog) | Glucagon-like peptide-1 (7-36 amide) |
| Molecular Weight | 5825.8 Da | 3297 Da |
| Half-Life | About 1-3 hours | 1-2 minutes |
| Amino Acids | 51 | 30 |
| Typical Dose | 0.05-0.2 U/kg per meal | Research-only: 0.1-1.0 pmol/kg/min |
| Route | Subcutaneous | Intravenous/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 11000 | 1200 |
| Research Status | Approved | Pre-clinical |
Insulin Aspart Benefits
- ✓Fast post-meal glucose lowering
- ✓Predictable onset
- ✓Flexible mealtime administration
- ✓Compatible with pump therapy
GLP-1 Benefits
- ✓beta-cell protection
- ✓improved insulin secretion
- ✓slower gastric emptying
- ✓lower postprandial glucose
Insulin Aspart Dosing
Inject SC immediately before meals|Titrate using glucose monitoring and carbohydrate intake|Can be used in insulin pumps or basal-bolus regimens
GLP-1 Dosing
0.1-1.0 pmol/kg/min IV infusion in research|0.5-10 nM in vitro|continuous delivery in animal studies
Insulin Aspart Side Effects
- ⚠Hypoglycemia
- ⚠Injection-site reactions
- ⚠Weight gain
GLP-1 Side Effects
- ⚠nausea at pharmacologic exposure
- ⚠tachyphylaxis with continuous exposure
- ⚠headache
Research Overview
Insulin Aspart
Research consistently shows faster onset and earlier peak action than regular human insulin. It is commonly studied for meal-time glycemic control and pump-based insulin delivery.
GLP-1
Native GLP-1 has a very short half-life because of rapid DPP-4 cleavage, so it is mainly used as a mechanistic research peptide. Across animal and cellular studies it reduces beta-cell apoptosis, improves insulin gene expression, and enhances islet resilience.
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