IGF-1 DES vs Somatostatin-14
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-1 DES | Somatostatin-14 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) |
| Molecular Weight | 7365 Da | 1637.9 Da |
| Half-Life | ~20-30 minutes | 1-3 minutes |
| Amino Acids | 67 | 14 |
| Typical Dose | — | Research-only; microgram-scale bolus or infusion |
| Route | — | Intravenous/Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 65 | 2000 |
| Research Status | Active Research | Pre-clinical |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
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