Histatin-5 vs Elamipretide
Head-to-head comparison of Histatin-5 (Human histatin 5) and Elamipretide (Elamipretide (MTP-131, SS-31)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | Elamipretide |
|---|---|---|
| Category | Dental & Oral | Muscle & Performance |
| Full Name | Human histatin 5 | Elamipretide (MTP-131, SS-31) |
| Molecular Weight | 3035 Da | 639.8 Da |
| Half-Life | minutes in saliva | 1-4 hours |
| Amino Acids | 24 | 4 |
| Typical Dose | 1-100 µM in research formulations | 0.01-0.25 mg/kg/day |
| Route | Topical/Oral rinse | Subcutaneous/Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 120 |
| Research Status | Pre-clinical | Clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
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