Hexapeptide-9 vs Tetracosactide
Head-to-head comparison of Hexapeptide-9 (Hexapeptide-9) and Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Hexapeptide-9 | Tetracosactide |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Hexapeptide-9 | Tetracosactide (ACTH 1-24, Cosyntropin) |
| Molecular Weight | 681.7 Da | 2933 Da |
| Half-Life | N/A | ~15 minutes |
| Amino Acids | 6 | 24 |
| Typical Dose | 0.01-1% in cosmetic formulations | 10–1000 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 12 | 220 |
| Research Status | Pre-clinical | Clinical/Pre-clinical |
Hexapeptide-9 Benefits
- ✓skin-repair support
- ✓collagen-matrix support
- ✓fine-line appearance reduction
- ✓topical rejuvenation
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Hexapeptide-9 Dosing
Topical serum/cream 0.01-1%|Apply once or twice daily|Use consistently for visible cosmetic effects
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Hexapeptide-9 Side Effects
- ⚠mild redness
- ⚠temporary stinging
- ⚠sensitivity in reactive skin
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Research Overview
Hexapeptide-9
Hexapeptide-9 appears in scientific and cosmetic literature related to wound repair, cell migration, and extracellular matrix support. The evidence base is smaller than for more established peptides, but it is a real research-backed cosmetic ingredient.
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
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