hBD-1 vs Cholecystokinin-8
Head-to-head comparison of hBD-1 (Human beta-defensin 1) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | hBD-1 | Cholecystokinin-8 |
|---|---|---|
| Category | Dental & Oral | Endocrine Peptides |
| Full Name | Human beta-defensin 1 | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 4490 Da | 1143.2 Da |
| Half-Life | minutes to hours | 1-2 min |
| Amino Acids | 36 | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | 1-10 µg/mL in experimental studies | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | Topical/Intraoral | endogenous secretion|research IV/SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 85 | 97 |
| Research Status | Pre-clinical | Endogenous |
hBD-1 Benefits
- ✓oral innate immunity
- ✓broad antimicrobial activity
- ✓biofilm suppression
- ✓periodontal support
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
hBD-1 Dosing
topical peptide exposure|cell-culture or mucosal models|repeat low-dose application in research
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
hBD-1 Side Effects
- ⚠protease degradation
- ⚠local irritation at high dose
- ⚠limited stability in saliva
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
hBD-1
hBD-1 has been studied as part of the oral mucosal defense system and is linked to host resistance against dental pathogens. Research spans periodontitis, candidiasis, and epithelial barrier biology.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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