GLP-1 vs Statherin
Head-to-head comparison of GLP-1 (Glucagon-like peptide-1 (7-36 amide)) and Statherin (Human statherin) — benefits, dosing, side effects, research data, and where to buy.
| Property | GLP-1 | Statherin |
|---|---|---|
| Category | Diabetes & Metabolic | Dental & Oral |
| Full Name | Glucagon-like peptide-1 (7-36 amide) | Human statherin |
| Molecular Weight | 3297 Da | 5380 Da |
| Half-Life | 1-2 minutes | minutes to hours in saliva |
| Amino Acids | 30 | 43 |
| Typical Dose | Research-only: 0.1-1.0 pmol/kg/min | 1-50 µM in experimental systems |
| Route | Intravenous/Subcutaneous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 95 |
| Research Status | Pre-clinical | Pre-clinical |
GLP-1 Benefits
- ✓beta-cell protection
- ✓improved insulin secretion
- ✓slower gastric emptying
- ✓lower postprandial glucose
Statherin Benefits
- ✓enamel pellicle stabilization
- ✓calcium phosphate homeostasis
- ✓remineralization support
- ✓anti-adhesion
GLP-1 Dosing
0.1-1.0 pmol/kg/min IV infusion in research|0.5-10 nM in vitro|continuous delivery in animal studies
Statherin Dosing
topical peptide exposure in vitro or ex vivo|salivary-mimetic coating studies|surface-conditioning protocols
GLP-1 Side Effects
- ⚠nausea at pharmacologic exposure
- ⚠tachyphylaxis with continuous exposure
- ⚠headache
Statherin Side Effects
- ⚠minimal systemic effects expected
- ⚠surface adsorption variability
- ⚠rapid enzymatic breakdown
Research Overview
GLP-1
Native GLP-1 has a very short half-life because of rapid DPP-4 cleavage, so it is mainly used as a mechanistic research peptide. Across animal and cellular studies it reduces beta-cell apoptosis, improves insulin gene expression, and enhances islet resilience.
Statherin
Statherin has been extensively studied as a key regulator of enamel mineral equilibrium and pellicle biology. It is used in biomimetic dentistry research to model or improve enamel protection and remineralization.
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