Statherin vs P11-4
Head-to-head comparison of Statherin (Human statherin) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Statherin | P11-4 |
|---|---|---|
| Category | Dental & Oral | Dental & Oral |
| Full Name | Human statherin | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 5380 Da | 1466 Da |
| Half-Life | minutes to hours in saliva | local activity for hours; peptide degraded over time |
| Amino Acids | 43 | 11 |
| Typical Dose | 1-50 µM in experimental systems | 0.5-5 mg per lesion |
| Route | Topical/Intraoral | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 40 |
| Research Status | Pre-clinical | Clinical |
Statherin Benefits
- ✓enamel pellicle stabilization
- ✓calcium phosphate homeostasis
- ✓remineralization support
- ✓anti-adhesion
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Statherin Dosing
topical peptide exposure in vitro or ex vivo|salivary-mimetic coating studies|surface-conditioning protocols
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Statherin Side Effects
- ⚠minimal systemic effects expected
- ⚠surface adsorption variability
- ⚠rapid enzymatic breakdown
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Statherin
Statherin has been extensively studied as a key regulator of enamel mineral equilibrium and pellicle biology. It is used in biomimetic dentistry research to model or improve enamel protection and remineralization.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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