Ghrelin vs hGHRH(1-44)
Head-to-head comparison of Ghrelin (Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue)) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ghrelin | hGHRH(1-44) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue) | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | 3367 Da | N/A |
| Half-Life | 20-30 minutes | 5-15 minutes |
| Amino Acids | 28 | 44 |
| Typical Dose | 1-3 mcg/kg | 0.1-1 mcg/kg |
| Route | Subcutaneous/Intravenous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 120 |
| Research Status | Clinical research | Clinical Research |
Ghrelin Benefits
- ✓increases GH pulses
- ✓supports appetite and energy intake
- ✓may support lean mass preservation
- ✓promotes recovery signaling
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
Ghrelin Dosing
1-3 mcg/kg SC or IV|repeat dosing in short research windows|titrate to GH response in monitored studies
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
Ghrelin Side Effects
- ⚠hunger/nausea
- ⚠transient flushing
- ⚠changes in glucose/insulin
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
Ghrelin
Ghrelin is the canonical ligand for the growth hormone secretagogue receptor and is used extensively as a reference compound in GH-axis research. Human and animal studies consistently show rapid, dose-dependent GH release after acyl-ghrelin administration.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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