Endomorphin-1 vs Insulin Aspart
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and Insulin Aspart (Insulin aspart (B28-Asp human insulin analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | Insulin Aspart |
|---|---|---|
| Category | Pain Management | Diabetes & Metabolic |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | Insulin aspart (B28-Asp human insulin analog) |
| Molecular Weight | 610.71 Da | 5825.8 Da |
| Half-Life | Minutes in plasma | About 1-3 hours |
| Amino Acids | 4 | 51 |
| Typical Dose | 0.1-10 ug per animal | 0.05-0.2 U/kg per meal |
| Route | Intrathecal / subcutaneous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 11000 |
| Research Status | Pre-clinical | Approved |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Insulin Aspart Benefits
- ✓Fast post-meal glucose lowering
- ✓Predictable onset
- ✓Flexible mealtime administration
- ✓Compatible with pump therapy
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Insulin Aspart Dosing
Inject SC immediately before meals|Titrate using glucose monitoring and carbohydrate intake|Can be used in insulin pumps or basal-bolus regimens
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Insulin Aspart Side Effects
- ⚠Hypoglycemia
- ⚠Injection-site reactions
- ⚠Weight gain
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
Insulin Aspart
Research consistently shows faster onset and earlier peak action than regular human insulin. It is commonly studied for meal-time glycemic control and pump-based insulin delivery.
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