Didemnin B vs Mambalgin-1
Head-to-head comparison of Didemnin B (Didemnin B) and Mambalgin-1 (Mambalgin-1 from Dendroaspis polylepis venom) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Didemnin B | Mambalgin-1 |
|---|---|---|
| Category | Experimental | Experimental |
| Full Name | Didemnin B | Mambalgin-1 from Dendroaspis polylepis venom |
| Molecular Weight | 1112.4 Da | 6,300 Da |
| Half-Life | N/A | Minutes to hours |
| Amino Acids | N/A | 57 |
| Typical Dose | 0.05-2 mg/m2 IV in early trials | 0.1-1 nmol intrathecal|10-100 nM in vitro|single-dose rodent studies |
| Route | Intravenous | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 55 |
| Research Status | Clinical | Pre-clinical |
Didemnin B Benefits
- ✓antineoplastic
- ✓antiviral
- ✓pro-apoptotic
- ✓immunomodulatory
Mambalgin-1 Benefits
- ✓ASIC channel inhibition
- ✓non-opioid analgesia research
- ✓sensory-neuron physiology
- ✓lead optimization for pain therapeutics
Didemnin B Dosing
historic IV phase I/II oncology regimens|dose escalation in early trials|no approved dosing regimen
Mambalgin-1 Dosing
Intrathecal pain-behavior studies|ASIC1a/ASIC1b electrophysiology|Acute dosing in rodents
Didemnin B Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠myelosuppression
Mambalgin-1 Side Effects
- ⚠Hypoactivity at high dose
- ⚠off-target ASIC blockade
- ⚠local irritation
Research Overview
Didemnin B
Didemnin B showed strong cytotoxic and antiviral activity in early literature and became an important scaffold for later marine drug development. Its clinical progress was limited by toxicity, but it remains highly cited as a foundational marine depsipeptide.
Mambalgin-1
Pre-clinical work shows mambalgin-1 can reduce pain behaviors by modulating proton-gated ion channels in peripheral and central pathways. It has become an important template for developing ASIC-targeted analgesics.
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