AICAR vs Secretin
Head-to-head comparison of AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | AICAR | Secretin |
|---|---|---|
| Category | Performance | Gastrointestinal |
| Full Name | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) | Human Secretin |
| Molecular Weight | 338.21 g/mol | 3055.4 Da |
| Half-Life | ~2-3 hours | 5-7 minutes |
| Amino Acids | Nucleoside analog | 27 |
| Typical Dose | — | 0.2 mcg/kg IV |
| Route | — | Intravenous |
| Purity | >99% | ≥98% |
| Studies Count | 180 | 800 |
| Research Status | Active Research | Clinical |
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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