AICAR
5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)
Nucleoside analog Amino Acids · MW: 338.21 g/mol
Amino Acids
Nucleoside analog
Molecular Weight
338.21 g/mol
Half-life
~2-3 hours
Research Score
75.0
Studies
180
Storage
-20°C long-term, 2-8°C short-term
What is AICAR?
AICAR is an AMP-activated protein kinase (AMPK) agonist that mimics the metabolic effects of exercise, enhancing endurance, fat oxidation, and mitochondrial biogenesis without physical training.
Key Benefits & Mechanisms
Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
Research Summary
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
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