Secretin vs DSIP
Head-to-head comparison of Secretin (Human Secretin) and DSIP (Delta Sleep-Inducing Peptide) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | DSIP |
|---|---|---|
| Category | Gastrointestinal | Performance |
| Full Name | Human Secretin | Delta Sleep-Inducing Peptide |
| Molecular Weight | 3055.4 Da | 848.8 Da |
| Half-Life | 5-7 minutes | ~15-25 minutes |
| Amino Acids | 27 | 9 |
| Typical Dose | 0.2 mcg/kg IV | 100-200 mcg |
| Route | Intravenous | SC / IV / Intranasal |
| Purity | ≥98% | — |
| Studies Count | 800 | 74 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
DSIP Benefits
- ✓Promotes deep delta wave sleep
- ✓Normalizes disrupted sleep patterns
- ✓Reduces cortisol and stress response
- ✓Pain modulating effects
- ✓Antioxidant properties
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
DSIP Dosing
Standard: 100-200 mcg SC or IV, 30-60 min before bed|Cycle: 10-14 days, 5-7 days off|Chronic insomnia: 100 mcg daily for 2-3 weeks|Can be combined with Ipamorelin pre-bed
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
DSIP Side Effects
- ⚠Common (Mild): Morning grogginess initially, mild headache
- ⚠Rare: Vivid dreams, temporary appetite changes
- ⚠Generally very well tolerated
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
DSIP
DSIP has moderate clinical evidence from European studies. Human trials show improved sleep quality and normalized sleep-wake cycles. Also studied for alcohol and opiate withdrawal. Unique mechanism distinct from traditional sleep aids.
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