Secretin vs IGF-1 LR3
Head-to-head comparison of Secretin (Human Secretin) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | IGF-1 LR3 |
|---|---|---|
| Category | Gastrointestinal | Performance |
| Full Name | Human Secretin | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 3055.4 Da | 9,117 Da |
| Half-Life | 5-7 minutes | ~20-30 hours |
| Amino Acids | 27 | 83 |
| Typical Dose | 0.2 mcg/kg IV | 20-100 mcg |
| Route | Intravenous | IM / SC |
| Purity | ≥98% | — |
| Studies Count | 800 | 298 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
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