Argireline vs Eyeseryl
Head-to-head comparison of Argireline (Acetyl Hexapeptide-3) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Argireline | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Acetyl Hexapeptide-3 | Acetyl Tetrapeptide-5 |
| Molecular Weight | 889.0 Da | 492.5 Da |
| Half-Life | N/A | N/A |
| Amino Acids | 6 | 4 |
| Typical Dose | 0.005-10% in finished cosmetic products | 0.5-2% in eye-area cosmetic products |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 48 | 18 |
| Research Status | Clinical | Clinical |
Argireline Benefits
- ✓expression-line softening
- ✓anti-wrinkle support
- ✓cosmetic skin smoothing
- ✓topical peptide stacking
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Argireline Dosing
Topical serum/cream 0.005-10%|Apply 1-2x daily to clean skin|Use consistently for 4-12 weeks
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Argireline Side Effects
- ⚠mild stinging
- ⚠redness or irritation
- ⚠allergic contact dermatitis
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Argireline
Acetyl hexapeptide-3 has both in vitro and small human-cosmetic studies supporting a reduction in wrinkle depth or wrinkle appearance. Its best-supported role is as a topical cosmetic peptide rather than a systemic drug.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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