Ac-SDKP vs BMP-2
Head-to-head comparison of Ac-SDKP (N-Acetyl-Seryl-Aspartyl-Lysyl-Proline) and BMP-2 (Recombinant Human Bone Morphogenetic Protein-2) — benefits, dosing, side effects, research data, and where to buy.
| Property | Ac-SDKP | BMP-2 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | N-Acetyl-Seryl-Aspartyl-Lysyl-Proline | Recombinant Human Bone Morphogenetic Protein-2 |
| Molecular Weight | 432.4 Da | 26000 Da |
| Half-Life | minutes | short, localized exposure |
| Amino Acids | 4 | 114 |
| Typical Dose | 10–100 µg/kg/day in pre-clinical studies | 1.5 mg/mL local implant |
| Route | Subcutaneous | Local/Implant |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 1500 |
| Research Status | Pre-clinical | Clinical |
Ac-SDKP Benefits
- ✓anti-inflammatory tissue remodeling
- ✓fibroblast modulation
- ✓microvascular protection
- ✓faster regenerative signaling
BMP-2 Benefits
- ✓promotes osteogenesis
- ✓supports nonunion healing
- ✓enhances scaffold-based repair
- ✓may improve defect fill
Ac-SDKP Dosing
Research-only systemic microdoses|short daily dosing in animal models|route varies by study
BMP-2 Dosing
local implantation on collagen sponge|single intraoperative dose|procedure-specific scaffold delivery
Ac-SDKP Side Effects
- ⚠GI upset
- ⚠hypotension at high exposure
- ⚠unknown long-term safety
BMP-2 Side Effects
- ⚠local inflammation
- ⚠ectopic bone formation
- ⚠edema
Research Overview
Ac-SDKP
Ac-SDKP has literature in tissue remodeling, angiogenesis, and organ repair models. Its strongest evidence is pre-clinical, where it modulates inflammation and fibrosis during healing.
BMP-2
rhBMP-2 has strong clinical and translational literature for bone regeneration, spinal fusion, and defect repair. Its use is primarily local because systemic exposure is not the intended mechanism.
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