Ac-SDKP vs rhPDGF-BB
Head-to-head comparison of Ac-SDKP (N-Acetyl-Seryl-Aspartyl-Lysyl-Proline) and rhPDGF-BB (Recombinant Human Platelet-Derived Growth Factor-BB) — benefits, dosing, side effects, research data, and where to buy.
| Property | Ac-SDKP | rhPDGF-BB |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | N-Acetyl-Seryl-Aspartyl-Lysyl-Proline | Recombinant Human Platelet-Derived Growth Factor-BB |
| Molecular Weight | 432.4 Da | 24.8 kDa |
| Half-Life | minutes | minutes |
| Amino Acids | 4 | 109 per chain (homodimer) |
| Typical Dose | 10–100 µg/kg/day in pre-clinical studies | 100 µg/g gel once daily |
| Route | Subcutaneous | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 400 |
| Research Status | Pre-clinical | Clinical |
Ac-SDKP Benefits
- ✓anti-inflammatory tissue remodeling
- ✓fibroblast modulation
- ✓microvascular protection
- ✓faster regenerative signaling
rhPDGF-BB Benefits
- ✓cell migration
- ✓fibroblast proliferation
- ✓collagen deposition
- ✓diabetic ulcer healing
Ac-SDKP Dosing
Research-only systemic microdoses|short daily dosing in animal models|route varies by study
rhPDGF-BB Dosing
Topical once daily|apply to clean wound bed|continue until complete granulation/closure
Ac-SDKP Side Effects
- ⚠GI upset
- ⚠hypotension at high exposure
- ⚠unknown long-term safety
rhPDGF-BB Side Effects
- ⚠local erythema
- ⚠pain
- ⚠edema
- ⚠theoretical tumor-promoting risk
Research Overview
Ac-SDKP
Ac-SDKP has literature in tissue remodeling, angiogenesis, and organ repair models. Its strongest evidence is pre-clinical, where it modulates inflammation and fibrosis during healing.
rhPDGF-BB
rhPDGF-BB has one of the strongest clinical wound-healing datasets among growth factors and is best known for chronic diabetic foot ulcers. Its efficacy is tied to chemotaxis and mitogenesis in fibroblasts, smooth muscle cells, and macrophage-lineage cells.
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