Tertiapin
Bee venom peptide Tertiapin
21 Amino Acids · MW: about 2.4 kDa
Amino Acids
21
Molecular Weight
about 2.4 kDa
Half-life
N/A
Research Score
4.2
Studies
85
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Tertiapin?
Tertiapin is a honeybee venom peptide that blocks inwardly rectifying potassium channels, especially GIRK and some Kir subtypes. It is used as a selective pharmacology tool in electrophysiology and cardiac research.
Key Benefits & Mechanisms
GIRK/Kir probe
electrophysiology tool
channel-lead scaffold
Research Summary
Tertiapin and the related tertiapin-Q analog are widely used to dissect potassium-channel function in excitable tissues. The peptide is valuable as a research tool because of its strong and relatively selective Kir inhibition.
Related Peptides
Eptifibatide
Eptifibatide
Eptifibatide is a cyclic heptapeptide antiplatelet drug derived from the barbourin motif of pygmy rattlesnake venom. It blocks the platelet glycoprotein IIb/IIIa receptor and is used to reduce thrombotic risk in acute coronary settings.
Venom-DerivedCrotamine
Crotamine
Crotamine is a basic 42-residue peptide from South American rattlesnake venom. It is a cell-penetrating toxin studied as a probe for ion channels and as a potential tumor-targeting delivery scaffold.
Venom-DerivedEchistatin
Echistatin
Echistatin is a small RGD-containing disintegrin from saw-scaled viper venom. It binds integrins and inhibits platelet adhesion, making it a classic tool in thrombosis and cell-adhesion research.
Venom-DerivedPsalmotoxin-1
Psalmotoxin-1 (PcTx1)
Psalmotoxin-1 is a tarantula venom peptide that selectively inhibits acid-sensing ion channel 1a. It is widely used to study pain signaling, ischemia, and neurodegenerative mechanisms.
Venom-Derived