PADRE
Pan HLA-DR-binding helper T-cell epitope
AKFVAAWTLKAAA Amino Acids · MW: 1347.56
Amino Acids
AKFVAAWTLKAAA
Molecular Weight
1347.56
Half-life
Minutes to hours; formulation-dependent
Research Score
4.4
Studies
88
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is PADRE?
PADRE is a synthetic promiscuous CD4+ helper T-cell epitope designed to bind many HLA-DR alleles. It is widely used in peptide vaccine research to improve helper T-cell priming and strengthen responses to linked antigens.
Key Benefits & Mechanisms
broad HLA-DR coverage
enhances CD4+ help
boosts peptide-vaccine immunogenicity
Research Summary
Extensively documented as a vaccine helper peptide in preclinical and translational studies. It is commonly conjugated or co-formulated with antigenic epitopes and adjuvants to increase immune breadth and response magnitude.
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