Nelipepimut-S
HER2/neu-derived peptide vaccine Nelipepimut-S (E75; KIFGSLAFL)
9 Amino Acids · MW: 995.2 Da
Amino Acids
9
Molecular Weight
995.2 Da
Half-life
minutes to hours
Research Score
4.0
Studies
30
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Nelipepimut-S?
A 9-mer HLA-A2/A3-restricted peptide from HER2/neu used as a vaccine antigen. It aims to expand cytotoxic T-cell responses against HER2-positive tumors.
Key Benefits & Mechanisms
HER2-targeted immunity
adjuvant vaccine use
minimal systemic toxicity
may reduce recurrence risk
Research Summary
E75 has been studied in breast cancer and other HER2-expressing tumors, often with GM-CSF. Trials show immunogenicity and acceptable safety, but definitive efficacy has been variable.
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