Mecasermin
Recombinant human insulin-like growth factor-1 (rhIGF-1)
70 Amino Acids · MW: 7649 Da
Amino Acids
70
Molecular Weight
7649 Da
Half-life
6 hours
Research Score
4.5
Studies
180
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Mecasermin?
Mecasermin is recombinant human IGF-1, used to bypass deficient GH signaling when endogenous IGF-1 production is inadequate. It acts downstream of growth hormone and directly activates IGF-1 receptors in target tissues.
Key Benefits & Mechanisms
linear growth in IGF-1 deficiency
direct IGF-1 receptor activation
anabolic signaling
tissue growth support
Research Summary
Mecasermin has substantial clinical literature in severe primary IGF-1 deficiency and related growth disorders. Research emphasizes its ability to increase growth in patients who do not respond adequately to GH alone, but its use is constrained by hypoglycemia risk.
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