MCH
Melanin-Concentrating Hormone
19 Amino Acids · MW: 2450 Da
Amino Acids
19
Molecular Weight
2450 Da
Half-life
~10-20 min
Research Score
4.7
Studies
92
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is MCH?
A hypothalamic peptide strongly associated with sleep promotion, especially REM and sleep consolidation. It is an important counterbalance to orexin-driven wakefulness and is studied for sleep quality and insomnia mechanisms.
Key Benefits & Mechanisms
MCHR1 agonism
sleep promotion
REM enhancement
Research Summary
MCH signaling is consistently linked to increased sleep propensity and altered REM architecture in preclinical models. Because it opposes arousal pathways, it is a useful peptide for studying sleep quality and sleep-state regulation.
Related Peptides
Orexin B
Hypocretin-2
Endogenous orexin-family peptide that supports wakefulness and arousal, with strong activity at OX2R. It is used in sleep-circuit and narcolepsy research.
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DSIP
Putative sleep-modulating nonapeptide first described as a delta-wave sleep associated factor. It remains a research peptide for insomnia and sleep architecture studies.
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PACAP-38
38-aa neuropeptide that couples light input to circadian timing in the suprachiasmatic nucleus. It is widely studied in sleep phase shifting and neuronal plasticity.
Sleep & CircadianNPS
Neuropeptide S
A small neuropeptide that modulates arousal, anxiety, and sleep-wake balance. It is notable in sleep research because it can influence both alertness and sleep fragmentation depending on context.
Sleep & Circadian