L-163,191
L-163,191 (nonpeptide growth hormone secretagogue receptor agonist)
N/A Amino Acids · MW: N/A
Amino Acids
N/A
Molecular Weight
N/A
Half-life
N/A
Research Score
3.9
Studies
45
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is L-163,191?
L-163,191 is a nonpeptide ghrelin receptor agonist developed as a tool compound for the GH secretagogue pathway. It is orally active in preclinical models and was used to show that small molecules can reproduce secretagogue-like GH release.
Key Benefits & Mechanisms
orally active GHSR agonism
increases pulsatile GH
raises IGF-1 in animals
useful oral research tool
Research Summary
L-163,191 helped establish the pharmacology of the ghrelin receptor before ghrelin itself was fully appreciated as the endogenous ligand. Preclinical studies show robust GH release and an oral activity profile that made it a leading tool compound for the field.
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