Hirudin
Hirudin, a natural 65-amino-acid direct thrombin inhibitor from the medicinal leech
Amino Acids
N/A
Molecular Weight
N/A
Half-life
N/A
Research Score
4.9
Studies
96
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Hirudin?
Hirudin binds thrombin with very high affinity and blocks fibrin formation. It is a classic anticoagulant scaffold used to guide later antithrombotic peptide design.
Key Benefits & Mechanisms
b1
Research Summary
Research
Related Peptides
Bivalirudin
Bivalirudin, a synthetic 20-amino-acid hirudin-derived direct thrombin inhibitor
Bivalirudin inhibits both the active site and exosite I of thrombin, reducing clot formation. It is widely known as a peptide anticoagulant used in cardiovascular intervention research and practice.
AnticoagulantLepirudin
Lepirudin, a recombinant desulfatohirudin direct thrombin inhibitor
Lepirudin is a recombinant hirudin analog that binds thrombin tightly and prevents fibrin clotting. It is one of the best-known peptide anticoagulants derived from the hirudin family.
AnticoagulantDesirudin
Desirudin, a recombinant hirudin variant used as a direct thrombin inhibitor
Desirudin blocks thrombin-mediated conversion of fibrinogen to fibrin and is a well-established hirudin-derived anticoagulant peptide. It is closely related to the natural leech peptide but optimized for therapeutic use.
AnticoagulantHirugen
Hirugen, a synthetic hirudin-derived peptide fragment that targets thrombin exosite I
Hirugen is a short peptide based on the C-terminal region of hirudin and is used to probe thrombin recognition. It acts as an anticoagulant lead by interfering with thrombin-substrate interactions.
Anticoagulant