H3K4M peptide
Histone H3 (1-10) K4M mutant peptide
10 Amino Acids · MW: ~1.1 kDa
Amino Acids
10
Molecular Weight
~1.1 kDa
Half-life
N/A
Research Score
4.2
Studies
82
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is H3K4M peptide?
Synthetic histone H3 N-terminal tail peptide with a lysine-to-methionine substitution at position 4. It is a research probe used to trap SET1/MLL family methyltransferases and study H3K4 mark deposition.
Key Benefits & Mechanisms
epigenetic target probe
H3K4 methyltransferase inhibition
chromatin biology research
Research Summary
Widely used in biochemical and structural studies as a substrate-competitive probe for H3K4 methyltransferase complexes and chromatin reader-writer interactions.
Related Peptides
H3K9M peptide
Histone H3 (1-10) K9M mutant peptide
Synthetic histone H3 tail peptide carrying a lysine-to-methionine substitution at position 9. It is used to probe G9a/GLP and SUV39 family lysine methyltransferases that write H3K9 methylation.
EpigeneticH3K27M peptide
Histone H3 K27M mutant peptide
Synthetic oncohistone-derived peptide with a lysine-to-methionine substitution at position 27. It inhibits PRC2 activity and is a classic tool for studying EZH2-mediated H3K27 methylation and Polycomb biology.
EpigeneticH3K36M peptide
Histone H3 K36M mutant peptide
Synthetic histone H3-derived peptide bearing a lysine-to-methionine substitution at position 36. It is used to investigate H3K36 methyltransferases such as NSD family enzymes and SETD2 in chromatin regulation.
EpigeneticH4K20M peptide
Histone H4 (16-25) K20M mutant peptide
Synthetic histone H4 tail peptide with a lysine-to-methionine substitution at position 20. It is used as a probe for enzymes that regulate H4K20 methylation, including SETD8 and SUV4-20 family members.
Epigenetic