Des-Acyl Ghrelin
Des-acyl ghrelin (unacylated ghrelin)
28 Amino Acids · MW: 3241 Da
Amino Acids
28
Molecular Weight
3241 Da
Half-life
20-30 minutes
Research Score
3.8
Studies
350
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Des-Acyl Ghrelin?
Des-acyl ghrelin is the same 28-amino-acid peptide as ghrelin but without the activating acyl group on Ser3. It does not strongly activate the classic ghrelin receptor, but it remains an important GH-pathway modulator in metabolic and endocrine research.
Key Benefits & Mechanisms
modulates GH-axis signaling
may support metabolic balance
research tool for ghrelin biology
may counterbalance acyl-ghrelin effects
Research Summary
Des-acyl ghrelin is widely studied alongside ghrelin to separate receptor-mediated effects from non-receptor-mediated actions. Literature suggests it can influence metabolism, cardiovascular signaling, and pituitary-related endpoints even though it is not a strong classic secretagogue.
Related Peptides
Ibutamoren
Ibutamoren mesylate (MK-677)
Ibutamoren is an orally active ghrelin receptor agonist that increases pulsatile growth hormone and IGF-1 secretion. It has been studied for effects on lean mass, recovery, and age-related anabolic support.
Growth HormoneAnamorelin
Anamorelin hydrochloride (ONO-7643)
Anamorelin is a selective ghrelin receptor agonist developed to stimulate appetite and growth hormone signaling. It has been investigated primarily in cancer cachexia and other wasting states.
Growth HormoneMacimorelin
Macimorelin acetate (AEZS-130)
Macimorelin is an orally active ghrelin mimetic used as a growth hormone stimulation agent. It produces a rapid GH rise after a single dose and is used clinically to help diagnose adult GH deficiency.
Growth HormoneCapromorelin
Capromorelin hydrochloride
Capromorelin is a ghrelin receptor agonist that stimulates growth hormone release and increases appetite. It is best known in veterinary medicine, but it has also been explored in human research settings.
Growth Hormone