Des(1-3)IGF-1
Des(1-3)-insulin-like growth factor-1
67 Amino Acids · MW: 7366 Da
Amino Acids
67
Molecular Weight
7366 Da
Half-life
20-30 minutes
Research Score
3.8
Studies
45
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Des(1-3)IGF-1?
Des(1-3)IGF-1 is a truncated IGF-1 variant lacking the first three N-terminal amino acids. This reduces binding to IGF-binding proteins and can increase receptor availability in experimental systems.
Key Benefits & Mechanisms
reduced igfbp binding
rapid IGF receptor signaling
myoblast activation
preclinical tissue-repair research
Research Summary
Des(1-3)IGF-1 is widely used in cell and animal studies to probe IGF-1 receptor signaling with less IGFBP sequestration. Literature suggests a stronger apparent bioavailability than native IGF-1, but it remains a research tool rather than a standard therapeutic.
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