Cortistatin-14
Cortistatin-14
14 Amino Acids · MW: 1720 Da
Amino Acids
14
Molecular Weight
1720 Da
Half-life
minutes
Research Score
4.2
Studies
70
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Cortistatin-14?
Cortistatin-14 is a neuropeptide related to somatostatin that also has direct immunoregulatory activity. It has been reported to suppress macrophage activation and reduce pro-inflammatory cytokine release in experimental inflammation.
Key Benefits & Mechanisms
reduces TNF-alpha
lowers IL-6 and IL-1beta
suppresses macrophage activation
supports anti-inflammatory signaling
Research Summary
Cortistatin-14 shows anti-inflammatory activity across immune and neuroimmune models, often overlapping with but distinct from somatostatin signaling. Literature suggests reduced cytokine production, improved inflammatory control, and potential relevance in autoimmune and gut-inflammatory settings.
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