Apamin
Bee venom peptide Apamin
18 Amino Acids · MW: 2027.2 Da
Amino Acids
18
Molecular Weight
2027.2 Da
Half-life
N/A
Research Score
4.2
Studies
85
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Apamin?
Apamin is an 18-residue peptide from honeybee venom that blocks small-conductance calcium-activated potassium channels. It is a classic neurophysiology tool for studying neuronal excitability and synaptic signaling.
Key Benefits & Mechanisms
SK-channel probe
neurophysiology research
lead scaffold
Research Summary
Apamin is one of the best-known bee venom peptides and remains important for studying SK channels in the brain and heart. Its biological activity is potent, but its direct therapeutic use is limited by neurotoxicity risk.
Related Peptides
Eptifibatide
Eptifibatide
Eptifibatide is a cyclic heptapeptide antiplatelet drug derived from the barbourin motif of pygmy rattlesnake venom. It blocks the platelet glycoprotein IIb/IIIa receptor and is used to reduce thrombotic risk in acute coronary settings.
Venom-DerivedCrotamine
Crotamine
Crotamine is a basic 42-residue peptide from South American rattlesnake venom. It is a cell-penetrating toxin studied as a probe for ion channels and as a potential tumor-targeting delivery scaffold.
Venom-DerivedEchistatin
Echistatin
Echistatin is a small RGD-containing disintegrin from saw-scaled viper venom. It binds integrins and inhibits platelet adhesion, making it a classic tool in thrombosis and cell-adhesion research.
Venom-DerivedPsalmotoxin-1
Psalmotoxin-1 (PcTx1)
Psalmotoxin-1 is a tarantula venom peptide that selectively inhibits acid-sensing ion channel 1a. It is widely used to study pain signaling, ischemia, and neurodegenerative mechanisms.
Venom-Derived