alpha-MSH
alpha-melanocyte-stimulating hormone
13 Amino Acids · MW: 1540 Da
Amino Acids
13
Molecular Weight
1540 Da
Half-life
minutes
Research Score
4.7
Studies
250
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is alpha-MSH?
alpha-MSH is an endogenous melanocortin peptide with broad anti-inflammatory and immunomodulatory actions. It has been investigated for reducing cytokine production, oxidative stress, and immune-cell activation in inflammatory disease models.
Key Benefits & Mechanisms
reduces TNF-alpha and IL-6
suppresses NF-kappaB activation
supports tissue-protective melanocortin signaling
may improve inflammatory resolution
Research Summary
alpha-MSH is one of the best-studied endogenous peptides for anti-inflammatory signaling, acting through melanocortin receptors to reduce pro-inflammatory cytokines. Preclinical literature supports effects in sepsis, autoimmune, and neuroinflammatory models, though human data remain limited.
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