Ac2-26
Annexin A1 N-terminal peptide Ac2-26
25 Amino Acids · MW: 2860 Da
Amino Acids
25
Molecular Weight
2860 Da
Half-life
minutes to hours
Research Score
4.4
Studies
120
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Ac2-26?
Ac2-26 is a synthetic N-terminal fragment of annexin A1 studied for its pro-resolving and anti-inflammatory signaling effects. It has been reported to reduce leukocyte trafficking and dampen inflammatory cytokine output in multiple preclinical models.
Key Benefits & Mechanisms
reduces TNF-alpha signaling
lowers IL-1beta and IL-6 output
promotes inflammation resolution
limits neutrophil recruitment
Research Summary
Annexin A1-derived peptides such as Ac2-26 activate pro-resolving pathways and can suppress NF-kappaB-linked inflammatory cascades. Animal studies show effects on cytokines, leukocyte adhesion, and tissue injury resolution, making it a credible immune-modulating research peptide.
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