Abaloparatide
Parathyroid hormone-related protein (PTHrP) analog
34 Amino Acids · MW: 3960.5 Da
Amino Acids
34
Molecular Weight
3960.5 Da
Half-life
about 1 hour
Research Score
4.7
Studies
92
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Abaloparatide?
Abaloparatide is a synthetic 34-amino-acid analog derived from PTHrP signaling biology. It preferentially activates the PTH1 receptor in a way that supports bone formation with less calcium burden than some older agents.
Key Benefits & Mechanisms
increases bone formation
improves BMD
lowers vertebral fracture risk
Research Summary
Clinical trial data show abaloparatide increases spine and hip BMD and reduces fracture risk in postmenopausal osteoporosis. It is a major approved peptide option for building bone density in high-risk patients.
Related Peptides
Parathyroid hormone (1-84)
Human parathyroid hormone full-length peptide
Parathyroid hormone (1-84) is the full-length native human PTH molecule. Intermittent exposure can drive bone remodeling toward bone formation, and it remains clinically relevant in calcium-bone disorders.
Bone & JointParathyroid hormone-related protein (1-36)
N-terminal PTHrP fragment
Parathyroid hormone-related protein (1-36) is an N-terminal fragment that activates the same receptor family as PTH. It has been studied as a potential bone-anabolic peptide in preclinical osteoporosis and osteoblast models.
Bone & JointCK2.3
BMP receptor II-derived CK2.3 peptide
CK2.3 is a synthetic peptide derived from the BMP receptor signaling region and studied as an anabolic bone and joint-tissue modulator. Preclinical work suggests it can promote bone formation and may help preserve cartilage in osteoarthritis models.
Bone & Joint