Tianeptine sodium vs Ibutamoren
Head-to-head comparison of Tianeptine sodium (Tianeptine sodium) and Ibutamoren (Ibutamoren mesylate (MK-677)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tianeptine sodium | Ibutamoren |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Tianeptine sodium | Ibutamoren mesylate (MK-677) |
| Molecular Weight | 458.94 Da | N/A |
| Half-Life | About 2.5 hours | about 24 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 12.5 mg 3 times daily | 10-25 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 280 | 180 |
| Research Status | Clinical | Clinical |
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
Ibutamoren Benefits
- ✓raises GH/IGF-1
- ✓increases appetite
- ✓supports lean mass retention
- ✓oral non-peptide secretagogue
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
Ibutamoren Dosing
10-25 mg orally once daily|take consistently at the same time each day|monitor fasting glucose and edema in longer studies
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Ibutamoren Side Effects
- ⚠increased appetite
- ⚠water retention/edema
- ⚠somnolence or lethargy
Research Overview
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
Ibutamoren
Clinical studies show oral ibutamoren reliably elevates GH and IGF-1 over 24 hours with once-daily dosing. Body composition and appetite effects vary by population, and development has been limited by metabolic side effects.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.