Tianeptine sodium vs Macimorelin
Head-to-head comparison of Tianeptine sodium (Tianeptine sodium) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tianeptine sodium | Macimorelin |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Tianeptine sodium | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 458.94 Da | N/A |
| Half-Life | About 2.5 hours | about 4-6 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 12.5 mg 3 times daily | 0.5 mg/kg single oral dose |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 280 | 120 |
| Research Status | Clinical | Clinical |
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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