Teduglutide vs Met-enkephalin
Head-to-head comparison of Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Teduglutide | Met-enkephalin |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Teduglutide (glycyl-2 human glucagon-like peptide-2 analog) | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 3752 Da | 573.67 Da |
| Half-Life | approximately 2-3 hours | 1-5 minutes in plasma |
| Amino Acids | 33 | 5 |
| Typical Dose | 0.05 mg/kg/day | 0.1-5 ug per animal |
| Route | Subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 300 | 1200 |
| Research Status | Clinical | Pre-clinical |
Teduglutide Benefits
- ✓mucosal-growth
- ✓absorption-support
- ✓barrier-repair
- ✓intestinal-adaptation
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Teduglutide Dosing
0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Teduglutide Side Effects
- ⚠abdominal pain
- ⚠fluid retention
- ⚠polyp/neoplasia monitoring needed
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Teduglutide
Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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