Secretin vs Neuropeptide S
Head-to-head comparison of Secretin (Human Secretin) and Neuropeptide S (Neuropeptide S) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Neuropeptide S |
|---|---|---|
| Category | Gastrointestinal | Cognitive Enhancement |
| Full Name | Human Secretin | Neuropeptide S |
| Molecular Weight | 3055.4 Da | 2203 Da |
| Half-Life | 5-7 minutes | Minutes to <1 hour |
| Amino Acids | 27 | 20 |
| Typical Dose | 0.2 mcg/kg IV | Research-only; no validated human dose |
| Route | Intravenous | Intracerebroventricular/Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 28 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
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