Secretin vs Davunetide
Head-to-head comparison of Secretin (Human Secretin) and Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Davunetide |
|---|---|---|
| Category | Gastrointestinal | Cognitive Enhancement |
| Full Name | Human Secretin | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) |
| Molecular Weight | 3055.4 Da | 796.9 Da |
| Half-Life | 5-7 minutes | short; minutes to low hours |
| Amino Acids | 27 | 8 |
| Typical Dose | 0.2 mcg/kg IV | 1-10 mg/day research range |
| Route | Intravenous | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 40 |
| Research Status | Clinical | Clinical/Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
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