Neuropeptide S vs NPY
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | NPY |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Neuropeptide S | Neuropeptide Y |
| Molecular Weight | 2203 Da | 4272 Da |
| Half-Life | Minutes to <1 hour | minutes |
| Amino Acids | 20 | 36 aa |
| Typical Dose | Research-only; no validated human dose | 1-10 µg preclinical range |
| Route | Intracerebroventricular/Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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