BMP-7 vs BMP-2
Head-to-head comparison of BMP-7 (Recombinant Human Bone Morphogenetic Protein-7) and BMP-2 (Recombinant Human Bone Morphogenetic Protein-2) — benefits, dosing, side effects, research data, and where to buy.
| Property | BMP-7 | BMP-2 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Recombinant Human Bone Morphogenetic Protein-7 | Recombinant Human Bone Morphogenetic Protein-2 |
| Molecular Weight | 35000 Da | 26000 Da |
| Half-Life | short, localized exposure | short, localized exposure |
| Amino Acids | 139 | 114 |
| Typical Dose | procedure-dependent local implant | 1.5 mg/mL local implant |
| Route | Local/Implant | Local/Implant |
| Purity | ≥98% | ≥98% |
| Studies Count | 700 | 1500 |
| Research Status | Clinical | Clinical |
BMP-7 Benefits
- ✓supports bone formation
- ✓may aid nonunion repair
- ✓promotes connective tissue regeneration
- ✓helps scaffold integration
BMP-2 Benefits
- ✓promotes osteogenesis
- ✓supports nonunion healing
- ✓enhances scaffold-based repair
- ✓may improve defect fill
BMP-7 Dosing
local implantation|single procedural exposure|research or device-specific delivery
BMP-2 Dosing
local implantation on collagen sponge|single intraoperative dose|procedure-specific scaffold delivery
BMP-7 Side Effects
- ⚠local swelling
- ⚠inflammation
- ⚠ectopic mineralization
BMP-2 Side Effects
- ⚠local inflammation
- ⚠ectopic bone formation
- ⚠edema
Research Overview
BMP-7
rhBMP-7 has a long history in preclinical and clinical literature for bone repair, particularly in challenging healing environments. Its cartilage-related research is less mature than BMP-2 but still relevant to musculoskeletal regeneration.
BMP-2
rhBMP-2 has strong clinical and translational literature for bone regeneration, spinal fusion, and defect repair. Its use is primarily local because systemic exposure is not the intended mechanism.
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