BMP-7 vs FGF2
Head-to-head comparison of BMP-7 (Recombinant Human Bone Morphogenetic Protein-7) and FGF2 (Recombinant Human Fibroblast Growth Factor 2) — benefits, dosing, side effects, research data, and where to buy.
| Property | BMP-7 | FGF2 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Recombinant Human Bone Morphogenetic Protein-7 | Recombinant Human Fibroblast Growth Factor 2 |
| Molecular Weight | 35000 Da | 17.2 kDa |
| Half-Life | short, localized exposure | minutes to <1 hour local |
| Amino Acids | 139 | 155 |
| Typical Dose | procedure-dependent local implant | 1–10 µg/cm²/day |
| Route | Local/Implant | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 700 | 1200 |
| Research Status | Clinical | Clinical |
BMP-7 Benefits
- ✓supports bone formation
- ✓may aid nonunion repair
- ✓promotes connective tissue regeneration
- ✓helps scaffold integration
FGF2 Benefits
- ✓angiogenesis
- ✓fibroblast proliferation
- ✓granulation tissue formation
- ✓accelerated re-epithelialization
BMP-7 Dosing
local implantation|single procedural exposure|research or device-specific delivery
FGF2 Dosing
Topical spray/gel daily|intralesional microdoses in studies|short cycles during active repair
BMP-7 Side Effects
- ⚠local swelling
- ⚠inflammation
- ⚠ectopic mineralization
FGF2 Side Effects
- ⚠local swelling
- ⚠pain
- ⚠fibroblast overgrowth/scarring
- ⚠theoretical malignancy concern
Research Overview
BMP-7
rhBMP-7 has a long history in preclinical and clinical literature for bone repair, particularly in challenging healing environments. Its cartilage-related research is less mature than BMP-2 but still relevant to musculoskeletal regeneration.
FGF2
FGF2 has extensive preclinical and clinical literature for skin ulcers, burns, and postsurgical repair, largely through angiogenic and mesenchymal-cell signaling. It remains one of the most studied repair factors for improving tissue perfusion and remodeling.
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