Plecanatide vs ACE-031
Head-to-head comparison of Plecanatide (Plecanatide) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Plecanatide | ACE-031 |
|---|---|---|
| Category | Gastrointestinal | Muscle & Performance |
| Full Name | Plecanatide | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | Approx. 1620 Da | ~95 kDa |
| Half-Life | Local intestinal action; systemic half-life not clinically meaningful | Days to weeks |
| Amino Acids | 16 | N/A |
| Typical Dose | 3 mg once daily | 0.1-3 mg/kg in early studies |
| Route | Oral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 75 |
| Research Status | Clinical | Clinical |
Plecanatide Benefits
- ✓improves-stool-frequency
- ✓supports-fluid-secretion
- ✓may-reduce-constipation
- ✓local-gut-action
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Plecanatide Dosing
3 mg PO daily|take with or without food|avoid when dehydrated
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Plecanatide Side Effects
- ⚠diarrhea
- ⚠abdominal-discomfort
- ⚠nausea
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Plecanatide
Clinical trials show plecanatide improves constipation outcomes with a generally favorable tolerability profile. Like linaclotide, it acts locally in the intestinal lumen via GC-C signaling rather than systemic hormone effects.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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