P11-4 vs Macimorelin
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | P11-4 | Macimorelin |
|---|---|---|
| Category | Dental & Oral | Growth Hormone |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 1466 Da | N/A |
| Half-Life | local activity for hours; peptide degraded over time | about 4-6 hours |
| Amino Acids | 11 | N/A |
| Typical Dose | 0.5-5 mg per lesion | 0.5 mg/kg single oral dose |
| Route | Topical/Intraoral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 120 |
| Research Status | Clinical | Clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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