P11-4 vs L-692,429
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and L-692,429 (L-692,429) — benefits, dosing, side effects, research data, and where to buy.
| Property | P11-4 | L-692,429 |
|---|---|---|
| Category | Dental & Oral | Growth Hormone |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | L-692,429 |
| Molecular Weight | 1466 Da | N/A |
| Half-Life | local activity for hours; peptide degraded over time | unknown / study-dependent |
| Amino Acids | 11 | N/A |
| Typical Dose | 0.5-5 mg per lesion | 0.03-0.1 mg/kg |
| Route | Topical/Intraoral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 30 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
L-692,429 Benefits
- ✓potent GHSR agonism
- ✓oral bioactivity in models
- ✓validates ghrelin pathway
- ✓useful research probe
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
L-692,429 Dosing
0.03-0.1 mg/kg in early studies|single oral or short-course research dosing|serial GH sampling recommended
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
L-692,429 Side Effects
- ⚠increased appetite
- ⚠glucose intolerance
- ⚠transient prolactin changes
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
L-692,429
L-692,429 was important in early GH secretagogue research because it showed that nonpeptide molecules could trigger robust GH release. It remains a classic tool compound for studying receptor-mediated GH pulsatility and appetite signaling.
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