Orexin-A vs Tianeptine sodium
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Tianeptine sodium (Tianeptine sodium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | Tianeptine sodium |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Hypocretin-1 (Orexin-A) | Tianeptine sodium |
| Molecular Weight | 3562 Da | 458.94 Da |
| Half-Life | Minutes to <1 hour | About 2.5 hours |
| Amino Acids | 33 | N/A |
| Typical Dose | Research-only; no validated human dose | 12.5 mg 3 times daily |
| Route | Intracerebroventricular/Intranasal | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 280 |
| Research Status | Pre-clinical | Clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Tianeptine sodium Benefits
- ✓mood improvement
- ✓anxiety reduction
- ✓cognitive clarity
- ✓stress adaptation
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Tianeptine sodium Dosing
12.5 mg oral 3x/day|25 mg/day oral|clinical antidepressant dosing
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Tianeptine sodium Side Effects
- ⚠nausea
- ⚠dizziness
- ⚠dependence risk
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Tianeptine sodium
Clinical studies support tianeptine as an antidepressant with a distinctive glutamatergic and neuroplasticity-related profile. Some evidence suggests cognitive benefits in mood-impaired populations, likely secondary to improved stress handling and affect.
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