Orexin-A vs hGHRH(1-44)
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | hGHRH(1-44) |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Hypocretin-1 (Orexin-A) | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | 3562 Da | N/A |
| Half-Life | Minutes to <1 hour | 5-15 minutes |
| Amino Acids | 33 | 44 |
| Typical Dose | Research-only; no validated human dose | 0.1-1 mcg/kg |
| Route | Intracerebroventricular/Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 120 |
| Research Status | Pre-clinical | Clinical Research |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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